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https://www.who.int/csr/don/2014_03_23_ebola/en/ https://www.euro.who.int/en/health-topics/communicable-diseases/pages/news/news/2014/08/ebola-outbreak-in-west-africa-declared-a-public-health-emergency-of-international-concern https://www.euro.who.int/en/health-topics/communicable-diseases/pages/news/news/2014/08/ebola-outbreak-in-west-africa-declared-a-public-health-emergency-of-international-concern https://www.euro.who.int/en/health-topics/communicable-diseases/pages/news/news/2014/08/ebola-outbreak-in-west-africa-declared-a-public-health-emergency-of-international-concern https://www.imi.europa.eu/news-eventspress-releases/innovative-medicines-initiative-launches-ebola-programme https://www.imi.europa.eu/news-eventspress-releases/innovative-medicines-initiative-launches-ebola-programme https://www.imi.europa.eu/projects-results/project-factsheets/ebodac https://www.imi.europa.eu/news-eventspress-releases/first-innovative-medicines-initiative-ebola-projects-get-underway https://www.imi.europa.eu/news-eventspress-releases/first-innovative-medicines-initiative-ebola-projects-get-underway https://clinicaltrials.gov/ct2/show/NCT02509494 https://www.imi.europa.eu/projects-results/project-factsheets/ebovac2 https://www.imi.europa.eu/projects-results/project-factsheets/ebovac2 https://www.ebovac.org/ebodac-symposium-report/ https://www.who.int/news/item/25-06-2020-10th-ebola-outbreak-in-the-democratic-republic-of-the-congo-declared-over-vigilance-against-flare-ups-and-support-for-survivors-must-continue https://www.who.int/news/item/25-06-2020-10th-ebola-outbreak-in-the-democratic-republic-of-the-congo-declared-over-vigilance-against-flare-ups-and-support-for-survivors-must-continue https://www.who.int/csr/don/4-august-2018-ebola-drc/en/ https://www.who.int/csr/don/4-august-2018-ebola-drc/en/ https://www.who.int/immunization/policy/position_papers/interim_ebola_recommendations_may_2019.pdf https://www.who.int/news/item/17-07-2019-ebola-outbreak-in-the-democratic-republic-of-the-congo-declared-a-public-health-emergency-of-international-concern https://www.who.int/news/item/17-07-2019-ebola-outbreak-in-the-democratic-republic-of-the-congo-declared-a-public-health-emergency-of-international-concern https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign https://odihpn.org/magazine/developing-a-gap-analysis-tool-to-improve-ebola-vaccine-acceptance-and-compliance-in-sub-saharan-africa/ https://odihpn.org/magazine/developing-a-gap-analysis-tool-to-improve-ebola-vaccine-acceptance-and-compliance-in-sub-saharan-africa/ https://www.jnj.com/johnson-johnson-announces-commitment-to-support-republic-of-rwandas-preparedness-against-ebola-outbreak https://www.jnj.com/johnson-johnson-announces-commitment-to-support-republic-of-rwandas-preparedness-against-ebola-outbreak https://www.ema.europa.eu/en/news/new-vaccine-prevention-ebola-virus-disease-recommended-approval-european-union https://www.who.int/emergencies/diseases/ebola/ebola-health-update---%C3%A9quateur-province-democratic-republic-of-the-congo-2020 https://www.who.int/emergencies/diseases/ebola/ebola-health-update---%C3%A9quateur-province-democratic-republic-of-the-congo-2020 https://www.who.int/emergencies/diseases/ebola/drc-2019 https://www.who.int/emergencies/diseases/ebola/drc-2019 https://www.ema.europa.eu/en/medicines/human/EPAR/zabdeno https://www.ema.europa.eu/en/medicines/human/EPAR/mvabea https://mesh.tghn.org/articles/event-ebodac-colloquium-2020/ https://www.who.int/csr/don/18-november-2020-ebola-drc/en/#:~:text=On%2018%20November%202020%2C%20the,EVD)%20outbreak%20in%20Equateur%20Province https://www.who.int/csr/don/18-november-2020-ebola-drc/en/#:~:text=On%2018%20November%202020%2C%20the,EVD)%20outbreak%20in%20Equateur%20Province https://www.who.int/csr/don/2014_03_23_ebola/en/ Rectangle
 
 
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Ministry of Health of Guinea informed WHO of EVD cases in south-eastern Guinea after 49 cases and 29 deaths were repo
WHO declared the 2014 2016 EVD outbreak in West Africa a PHEIC after 1,779 cases and 961 deaths were reported2
WHO declared the 2018 2020 10th EVD outbreak in DRC a PHEIC after 2,522 cases and 1,698 deaths were reported19
IMI Ebola+ programme launched3
First IMI Ebola project began5 7 First-in-human Phase 1 clinical trials of the vaccine regimen began in the UK and US
First clinical trials of vaccine regimen in Kambia, Sierra Leone (EBOVAC-Salone)10
First clinical trials of vaccine regimen in Kenya and Uganda (EBOVAC1)8,9
Zabdeno, Mvabea vaccine regimen received positive opinion from the EMA for preventative use in countries at risk of E
SAGE recommended the administration of the Janssen Ebola two-dose vaccine regimen (Zabdeno , Mvabea )* to individuals
Ministry of Health of DRC declared the beginning of the 2018 2020 10th EVD outbreak in DRC after four of six samples
Rwanda FDA approved the use of the Janssen Ebola two-dose vaccine regimen (Zabdeno , Mvabea )*20
Zabdeno , Mvabea  vaccine regimen received approval for marketing under exceptional circumstances for prophylactic us
WHO declared the beginning of the 11th EVD outbreak in DRC after 6 cases and 4 deaths were reported24
WHO declared the 2018 2020 10th EVD outbreak in DRC over25 3,481 total cases 2,299 total deaths
Minister of Health of the DRC declared the end of the 11th outbreak of EVD in DRC29 130 total cases 55 total deaths
EBODAC project launched4 The EBODAC consortium began formative research, discussed strategies for community engagemen
EBODAC Symposium13 Topics discussed included community engagement, communications and technology in Ebola clinical tr
EBODAC Virtual Colloquium28 Topics discussed included  Trust & Community Engagement  and  Rumour Management
Community engagement initiatives, communication strategies, and technology pieces were launched in Sierra Leone11
23 March 2014
8 August 2014
17 July 2019
November 2014
January 2015
September 2015
April 2015
1 July 2020
1 June 2020
25 June 2020
18 November 2020
December 2014
February 2016
October 2020
September 2015
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WHO declared the 2014 2016 EVD outbreak in West Africa over14 28,616 total cases 11,310 total deaths
25 June 2016
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First exploratory study in Sierra Leone of iris scanning in children15
First exploratory study of iris scanning in children in Belgium15
March 2017
June 2016
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Pilot of the Mobile Training and Support platform (MOTS)16
Mid-2018
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Pilot of 3C Gap Analysis Tool21
September 2019
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Umurinzi Ebola vaccination programme launched in Rwanda, supported by EBODAC22
December 2019
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The EBODAC team began working in the DRC
1 October 2019
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First clinical trials of vaccine regimen in France (EBOVAC2)12
January 2016
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29 May 2020
7 May 2019
1 August 2018
30 September 2019
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Key dates for the ebodac project
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EBODAC timeline and key dates
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Scroll left and right to view the timeline or click on the timeline and use the arrow keys
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3C: Communication, Community Engagement and Compliance Management; DRC: Democratic Republic of the Congo; EBODAC: Ebo
World Health Organization  Emergencies preparedness, response  Ebola virus disease in Guinea; Disease outbreak news;
 
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DEVELOPMENT OF THE JANSSEN TWO-DOSE EBOLA VACCINE REGIMEN (Ad26 ZEBOV  ZABDENO  , MVA-BN-Filo  MVABEA  )*
Establishment of the EBODAC project
Ebola virus disease (EVD) is a deadly disease in humans, with increasingly frequent outbreaks of EVD having plagued A
The Zabdeno , Mvabea  two-dose vaccine regimen, which the Ebola+ programme was designed to support, has received appr
The Ebola Vaccine Deployment, Acceptance and Compliance (EBODAC) project was designed to develop strategies and tools
EBOVAC1, EBOVAC2, EBOVAC3, EBOMAN and EBODAC are among the projects funded under the IMI Ebola+ programme 4,5    The
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   In addition, projects to develop rapid diagnostic tests in order to determine whether someone is infected with Ebo
https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign https://ec.europa.eu/commission/presscorner/detail/en/IP_20_1248 https://www.ema.europa.eu/en/news/new-vaccine-prevention-ebola-virus-disease-recommended-approval-european-union https://www.ema.europa.eu/en/news/new-vaccine-prevention-ebola-virus-disease-recommended-approval-european-union https://clinicaltrials.gov/ct2/show/NCT02509494 https://www.ebovac.org/ https://www.imi.europa.eu/news-eventspress-releases/first-innovative-medicines-initiative-ebola-projects-get-underway https://www.euro.who.int/en/health-topics/communicable-diseases/pages/news/news/2014/08/ebola-outbreak-in-west-africa-declared-a-public-health-emergency-of-international-concern https://www.euro.who.int/en/health-topics/communicable-diseases/pages/news/news/2014/08/ebola-outbreak-in-west-africa-declared-a-public-health-emergency-of-international-concern https://www.cdc.gov/vhf/ebola/outbreaks/index-2018.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fvhf%2Febola%2Foutbreaks%2Findex.html https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign
References CDC  40 Years of Ebola Virus Disease around the World  August 9, 2018    WHO Europe  Ebola outbreak in Wes
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Issues faced by the EBODAC consortium
Absence of a national ID card While it is always important to ensure that the correct person is attending clinic visi
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The EBODAC consortium faced several hurdles while they were supporting EBOVAC trials in Kambia, Sierra Leone  In part
Issues faced during the 2014 Ebola outbreak in West Africa
Issues typically faced in an outbreak setting
The successful development and deployment of a vaccine is faced with difficulties, especially when working in resourc
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Issues with trust faced during the Ebola outbreak in the Democratic Republic of the Congo, 2019
EBODAC: Addressing the issues faced in Sierra Leone
The role of the EBODAC consortium was to address the issues faced during the Ebola vaccine trials in Sierra Leone in
Introduction to the EBODAC project
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Key learnings of the EBODAC project
Building trust around clinical trials and vaccination deployment    Invest in understanding context-specific factors,
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The EBODAC project contributed to gaining lessons and experiences from the field to build a more prepared community f
Members of the EBODAC team at the consortium meeting in Uganda
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Key learnings of the EBODAC project
Building trust around clinical trials and vaccination deployment    Invest in understanding context-specific factors,
The EBODAC project contributed to building lessons and tools from the field to build a more prepared community for fu
TBC
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Take-home messages    Best practice around partnership requires collaboration at both a global and a local level    
 Application of EBODAC for current future vaccine programmes
Key learnings from the EBODAC project can be used to guide current and future vaccine programmes, particularly when c
Umurinzi Ebola vaccine campaign The Unprecedented Movement to drive a Unified Rwandan Initiative for National ZEBOVAC
Polygon https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign
*As of 16 December 2020, Zabdeno  (Ad26 ZEBOV) and Mvabea  (MVA-BN-Filo) have been approved by the European Commissio
 
CONTINUE READING
 Application of EBODAC for current future vaccine programmes
Key learnings from the EBODAC project can be used to guide current and future vaccine programmes, particularly when c
Umurinzi Ebola vaccine campaign The Unprecedented Movement to drive a Unified Rwandan Initiative for National ZEBOVAC
Polygon https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign
*As of 16 December 2020, Zabdeno  (Ad26 ZEBOV) and Mvabea  (MVA-BN-Filo) have been approved by the European Commissio
 
CONTINUE READING
 
Partnering of Umurinzi with EBODAC
 Application of EBODAC for current future vaccine programmes
Key learnings from the EBODAC project can be used to guide current and future vaccine programmes, particularly when c
Umurinzi Ebola vaccine campaign The Unprecedented Movement to drive a Unified Rwandan Initiative for National ZEBOVAC
Polygon https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign
*As of 16 December 2020, Zabdeno  (Ad26 ZEBOV) and Mvabea  (MVA-BN-Filo) have been approved by the European Commissio
 
CONTINUE READING
 
COVID-19 Mobile messaging has been further implemented in Rwanda and Sierra Leone to inform participants on COVID-19
 Application of EBODAC for current future vaccine programmes
Key learnings from the EBODAC project can be used to guide current and future vaccine programmes, particularly when c
Umurinzi Ebola vaccine campaign The Unprecedented Movement to drive a Unified Rwandan Initiative for National ZEBOVAC
Polygon https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign https://www.moh.gov.rw/news-detail/the-ministry-of-health-launched-umurinzi-ebola-vaccine-program-campaign
*As of 16 December 2020, Zabdeno  (Ad26 ZEBOV) and Mvabea  (MVA-BN-Filo) have been approved by the European Commissio
 
CONTINUE READING
 
 
GAP Analysis Tool The WHO s Global Ebola Vaccine Implementation Team (GEVIT) Practical Guidance on the Use of Ebola V
https://www.who.int/csr/resources/publications/ebola/gevit-guide/en/ https://www.who.int/csr/resources/publications/ebola/gevit-guide/en/
Reference WHO, Emergencies preparedness, response  Global Ebola Vaccine Implementation Team (GEVIT) Practical Guidanc
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Gap analysis format
 
 
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